Antioxidant effects of proanthocyanidin from grape seed on hepatic tissue injury in diabetic rats

نویسندگان

  • Esrafil Mansouri
  • Layasadat Khorsandi
  • Hassan Ali Abedi
چکیده

OBJECTIVES Diabetes plays an important role in the induction of the liver injury. Grape seed proanthocyanidin (GSP) have a wide range of medicinal properties against oxidative stress. In this study we evaluated antioxidant effects of GSP on liver in streptozotocin-induced diabetic rats. MATERIALS AND METHODS Thirty male Sprague-Dawley rats were divided into three groups: control, untreated diabetic and diabetic rats treated with GSP. Diabetes was induced in rats by intraperitoneal injection of streptozotocin (50 mg/kg). GSP were administered via oral gavage (200 mg/kg) for 4 weeks. RESULTS GSP produced significant hepatoprotective effects by decreasing activities of serum aminotransferases and alkaline phosphatase, and decreasing liver malondialdehyde and bilirubin (P<0.05) levels. It increased liver superoxide dismutase, catalase and glutathione peroxidase activities and albumin level (P<0.05). Administration of GSP significantly ameliorated structural changes induced in liver of diabetic rats. CONCLUSION GSP have protective effects against hepatic tissue injury due to antioxidant properties.

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Antioxidant effects of proanthocyanidin from grape seed on hepatic tissue injury in diabetic rats

Objective(s):Diabetes plays an important role in the induction of the liver injury. Grape seed proanthocyanidin (GSP) have a wide range of medicinal properties against oxidative stress. In this study we evaluated antioxidant effects of GSP on liver in streptozotocin-induced diabetic rats. Materials and Methods: Thirty male Sprague–Dawley rats were divided into three groups: control, untreated d...

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عنوان ژورنال:

دوره 17  شماره 

صفحات  -

تاریخ انتشار 2014